To assess the performance of selected natural anticoagulants suing liver biopsy as the gold standard.
Compare performance of natural anticoagulants with traditional noninvasive methods
We did study of Haemostatic Factors (ONLY) as Biomarkers of Significant Liver Fibrosis in Patients with Chronic Hepatitis C ( see below abstract) . We found it a negative study and challenged to be published. So we did reanalysis and included the results of fibroscn and other noninvasive score APRI, FIB-4 AND AST/ALT ratio and we want rewrite it after combining all these markers and score.
Importance: most of the studies in hematologic factors in liver disease did not assess liver fibrosis in large biopsy study….most studies for hematology assess this in cirrhotic ( but not patient with less degree of fibrosis)
What is needed:
To write the manuscript with new objective and including noninvasive scores and fibroscan in addition to the hemostatic factors
Rearrange and include tables
Update and included relevant references
Background & Aims
Hemostatic factors are affected in chronic liver disease (CLD). Evidence regarding their use as noninvasive markers of CLD severity is scarce. We aimed to study the association between the levels of hemostatic factors and the severity of liver fibrosis in a large cohort of chronic HCV patients.
A cross sectional study was conducted on 402 adults with HCV. Liver biopsy and blood tests including platelet count, prothrombin time, international normalized ratio (INR), thrombin time (TT), antithrombin (AT), reptilase time (RT), fibrinogen, factor VII, protein C (PC), protein S(PS), free protein S, and C4 binding protein (C4BP) were performed. Variables significantly associated with significant (≥F2, Metavir) fibrosis on univariate analysis were included in a multivariate logistic regression model.
Of the 402 eligible participants, 377 patients were included in the analysis. Significant fibrosis was present in 37.4%. INR increased while AT and PC decreased with increase in fibrosis stage (p value for all <0.001). C4BP levels reduction was associated with significant (≥F2) fibrosis (OR, 0.98; 95% CI: 0.97-0.99) adjusting for other parameters at multivariable analysis, so that as C4BP increases by one point, odds of having ≥F2 fibrosis decreases by 2%.
This study demonstrates a close relationship between hemostatic factors and histologic fibrosis progression in a large cohort of HCV patients. C4BP has the strongest association and could be used as a potential noninvasive marker of liver fibrosis. Further studies to validate this association are needed.
Bu iş için 16 freelancer ortalamada $1600 teklif veriyor
Hey i have a medical background and i have been writing in medical field. Plz have a look on my samples provided Relevant Skills and Experience Research Technical writing Proposal writing Medical writing
Hello there . If you need regular odds data , pre-match markets, live markets, live results and approved double checked results... And Live Video Streams..... Monthly payments ( details over chat ) I can provide you Daha Fazla