Abstract: Original Article
The association of consanguinity and family history to the heart diseases, i.e. ischemic heart disease (IHD), valvular heart disease (VHD), and cardiomyopathies (CMP), has been investigated in a hospital population. The inbreeding rates among IHD patients were 58.71%, VHD 60.65% and CMP 60.60%. The coefficient of inbreeding (F) calculated for IHD, VHD, CMP and associated cardiovascular diseases (A-CVD) was 0.0313, 0.0357, 0.0269 and 0.017, respectively. The F-value for the whole sample was 0.0306. There were 156 (31.29) families with positive family history and 344 (68.8%) were with negative family history. Relative risk for cardiovascular disease in positive family history compared to negative family history is 2.106 (CL = 1.97-2.36) and odds ratio was 3.51 (CL = 2.85-4.31). First cousins were significantly (P<0.05) affected with cardiovascular diseases compared to unrelated couples.
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